Trimethylsilyldiazomethane → Methyl 2-((2,5-dichloropyrimidin-4-yl)amino)benzoate
反応式
[Cl:1][C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=2[C:11]([OH:13])=[O:12])[C:5]([Cl:18])=[CH:4][N:3]=1.[CH3:19][Si](C=[N+]=[N-])(C)C>C(Cl)Cl.CO.C(OCC)C>[Cl:1][C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=2[C:11]([O:13][CH3:19])=[O:12])[C:5]([Cl:18])=[CH:4][N:3]=1参加物
5
実験手順
To a solution of 2-(2,5-dichloropyrimidin-4-ylamino)benzoic acid (300 mg, 1.1 mmol) in DCM/MeOH (10/5 mL) is added trimethylsilyl diazomethane in ethyl ether solution (2.0 M, 2 mL). The mixture is stirred for 30 min and concentrated to afford methyl 2-(2,5-dichloropyrimidin-4-ylamino)benzoate as yellow solid.
後処理
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-d8a10ade9d9148cd9135202927534141
- 出典データセット
- uspto-grants-2013_05
- 特許番号
- US08440681B2
反応ノート
読み込み中…