Potassium Hydroxide → 2-Aminoadamantan-1-ol
反応式
[C:1]123[CH2:13][CH:8]4[CH2:9][CH:10]([CH2:12][CH:6]([CH2:7]4)[CH:5]1[NH:4]C(=O)[O:2]2)[CH2:11]3.[OH-].[K+]>O1CCOCC1>[NH2:4][CH:5]1[CH:6]2[CH2:7][CH:8]3[CH2:9][CH:10]([CH2:11][C:1]1([OH:2])[CH2:13]3)[CH2:12]2参加物
4
実験手順
2-Oxa-4-azatetracyclo[6.3.1.16,10.01,5]tridecan-3-one (76 mg, 0.395 mmol) in 1,4-dioxane (1 mL) was stirred with 5 M aqueous potassium hydroxide at 70° C. for 1 day. After completion of the reaction, the reaction solution was extracted with chloroform, and the organic layer was dried over anhydrous sodium sulfate and evaporated under reduced pressure to give the desired product (70% yield).
後処理
- customAfter completion of the reaction
- extractionthe reaction solution was extracted with chloroform
- dry with materialthe organic layer was dried over anhydrous sodium sulfate
- customevaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-16b0f917b0af4e0fb8be44be17ed4eba
- 出典データセット
- uspto-grants-2013_05
- 特許番号
- US08440666B2
反応ノート
読み込み中…