Potassium Hydroxide → 2-Aminoadamantan-1-ol

HRID 2092025

反応式

HRID 2092025 の反応式
[C:1]123[CH2:13][CH:8]4[CH2:9][CH:10]([CH2:12][CH:6]([CH2:7]4)[CH:5]1[NH:4]C(=O)[O:2]2)[CH2:11]3.[OH-].[K+]>O1CCOCC1>[NH2:4][CH:5]1[CH:6]2[CH2:7][CH:8]3[CH2:9][CH:10]([CH2:11][C:1]1([OH:2])[CH2:13]3)[CH2:12]2

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 28074452-Oxa-4-azatetracyclo[6.3.1.16,10.01,5]tridecan-3-one

生成物 1

HCID 124667122-Aminoadamantan-1-ol収率 70%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

2-Oxa-4-azatetracyclo[6.3.1.16,10.01,5]tridecan-3-one (76 mg, 0.395 mmol) in 1,4-dioxane (1 mL) was stirred with 5 M aqueous potassium hydroxide at 70° C. for 1 day. After completion of the reaction, the reaction solution was extracted with chloroform, and the organic layer was dried over anhydrous sodium sulfate and evaporated under reduced pressure to give the desired product (70% yield).

後処理

  1. customAfter completion of the reaction
  2. extractionthe reaction solution was extracted with chloroform
  3. dry with materialthe organic layer was dried over anhydrous sodium sulfate
  4. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-16b0f917b0af4e0fb8be44be17ed4eba
出典データセット
uspto-grants-2013_05
特許番号
US08440666B2

関連ノート

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