4-Pyridinemethanamine → (S)-1-Methoxy-3-(pyridin-4-ylmethylamino)propan-2-ol
反応式
[CH3:1][O:2][CH2:3][C@@H:4]1[O:6][CH2:5]1.[N:7]1[CH:12]=[CH:11][C:10]([CH2:13][NH2:14])=[CH:9][CH:8]=1>CO>[CH3:1][O:2][CH2:3][C@@H:4]([OH:6])[CH2:5][NH:14][CH2:13][C:10]1[CH:11]=[CH:12][N:7]=[CH:8][CH:9]=1参加物
4
反応条件
- 温度
- 120 °C
実験手順
(R)-(−)-Glycidyl methyl ether (88 mg, 1 mmol) and 4-picolylamine (108 mg, 1 mmol) in methanol (1 mL) were sealed in a reaction tube and heated at 120° C. for 30 minutes with stirring and microwave irradiation. The solvent was removed by vacuum distillation. The resulting residue was purified by silica gel column chromatography (ethyl acetate) to give the desired product (17% yield).
後処理
- custommicrowave irradiation
- customThe solvent was removed by vacuum distillation
- customThe resulting residue was purified by silica gel column chromatography (ethyl acetate)
出典と根拠
- ORDレコード
- ord-b3ea38495ad7475f82fda0a7f9e8f9aa
- 出典データセット
- uspto-grants-2013_05
- 特許番号
- US08440666B2
反応ノート
読み込み中…