Hydrochloric Acid → Ethyl 2-(5-bromo-4-amino-6-oxopyridazin-1(6H)-yl)acetate
反応式
[Br:1][C:2]1[C:7](=[O:8])[N:6]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:5]=[CH:4][C:3]=1[NH:15]CC1C=CC(OCC)=C(OC)C=1.Cl>C(O)C>[Br:1][C:2]1[C:7](=[O:8])[N:6]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:5]=[CH:4][C:3]=1[NH2:15]参加物
4
反応条件
- 温度
- 90 °C
実験手順
Ethyl 2-[5-bromo-4-(4-ethoxy-3-methoxybenzylamino)-6-oxopyridazin-1(6H)-yl]acetate (570 mg, 1.29 mmol) in ethanol (11 mL) was stirred with concentrated hydrochloric acid (3.4 mL) at 90° C. for 4 hours. After cooling, the solvent was removed by distillation, and the residue was stirred with ethanol (10 mL) and 4 M hydrogen chloride-1,4-dioxane (1 mL) at 90° C. for 1 hour. After cooling, the solvent was removed by distillation. Toluene was added, and the resulting crystals were collected by filtration as the desired product (184 mg, 52% yield).