Ammonia → 3,4-Dihydro-2H-1-benzopyran-4-amine

HRID 2092164ノート

反応式

HRID 2092164 の反応式
CO[N:3]=[C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[O:7][CH2:6][CH2:5]1.CON=C1C2C(=CC=C(C)C=2)OCC1.N>>[O:7]1[C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:4]([NH2:3])[CH2:5][CH2:6]1

参加物

4

反応物 3

HCID 222AmmoniaHCID 54035320Chroman-4-one O-methyl-oximeHCID 86605441(4E)-N-Methoxy-6-methyl-3,4-dihydro-2H-1-benzopyran-4-imine

生成物 1

HCID 49619573,4-Dihydro-2H-1-benzopyran-4-amine

実験手順

The title compound was prepared using the procedure as described in Example 7B, substituting the product of Example 16A for the product of Example 7A. 1H NMR (300 MHz, DMSO-d6) δ ppm 7.32 (dd, J 1.0 and 7.5 Hz, 1H), 7.05 (m, 1H), 6.81 (m, 1H), 6.70 (dd, J 1.0 and 7.5 Hz, 1H), 4.27-4.08 (m, 2H), 3.83 (t, J 6.0 Hz, 1H), 2.03-1.66 (m, 4H). MS (DCI/NH3) m/e 150 (M+H)+.

出典と根拠

ORDレコード
ord-1ff257f7d91d406fbd18fa2cdfbbf7ad
出典データセット
uspto-grants-2013_05
特許番号
US08440691B2

反応ノート

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