Hydrochloric Acid → 5-benzyloctahydro-1H-pyrrolo[3,4-c]pyridine-2,5-diium chloride

HRID 2092211ノート

反応式

HRID 2092211 の反応式
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]2[CH2:14][N:15](C(OC(C)(C)C)=O)[CH2:16][CH:10]2[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:24].C(OCC)C>C(O)C.C(O)(C)C>[Cl-:24].[CH2:1]([NH+:8]1[CH2:13][CH2:12][CH:11]2[CH2:14][NH2+:15][CH2:16][CH:10]2[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-:24]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 68725101tert-butyl 5-benzylhexahydro-1H-pyrrolo[3,4-c]pyridine-2(3H)-carboxylate

生成物 1

HCID 866476885-benzyloctahydro-1H-pyrrolo[3,4-c]pyridine-2,5-diium chloride

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 3776Isopropanol溶媒

実験手順

1.355 g of tert-butyl 5-benzylhexahydro-1H-pyrrolo[3,4-c]pyridine-2(3H)-carboxylate (4.28 mmol) were dissolved in 10 ml of ethanol. To the solution 20 ml of 5 N HCl in isopropanol were added and the obtained mixture was stirred at room temperature for 16 h. After addition of diethyl ether the product precipitated. The product was filtered and after an additional washing with diethyl ether, the product was dried. Additional product was obtained by concentration of the filtrates and crystallization from diethyl ether. Combined amounts of product were 1.07 g.

後処理

  1. customprecipitated
  2. filtrationThe product was filtered
  3. washafter an additional washing with diethyl ether
  4. customthe product was dried
  5. customAdditional product was obtained by concentration of the filtrates and crystallization from diethyl ether

出典と根拠

ORDレコード
ord-880c6940d7a44c1bb8358e884d191516
出典データセット
uspto-grants-2013_05
特許番号
US08440694B2

反応ノート

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