(S)-1-Hydrazino-butan-2-ol → (S)-1-[5-(2-Chloro-6-methyl-pyridin-4-yl)-3-(3-methoxy-5-trifluoromethyl-phenylamino)-[1,2,4]triazol-1-yl]butan-2-ol

HRID 2092219ノート

反応式

HRID 2092219 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([NH:10][C:11](=[N:14][C:15]2[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[C:17]([O:25][CH3:26])[CH:16]=2)SC)=O)[CH:5]=[C:4]([CH3:27])[N:3]=1.[NH:28]([CH2:30][C@@H:31]([OH:34])[CH2:32][CH3:33])[NH2:29]>C(O)C>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[N:28]([CH2:30][C@@H:31]([OH:34])[CH2:32][CH3:33])[N:29]=[C:11]([NH:14][C:15]3[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[C:17]([O:25][CH3:26])[CH:16]=3)[N:10]=2)[CH:5]=[C:4]([CH3:27])[N:3]=1

参加物

4

反応物 2

HCID 28082624(S)-1-Hydrazino-butan-2-olHCID 1361160191-(2-Chloro-6-methyl-pyridine-4-carbonyl)-3-(3-methoxy-5-trifluoromethyl-phenyl)-2-methyl-isothiourea

生成物 1

HCID 86644738(S)-1-[5-(2-Chloro-6-methyl-pyridin-4-yl)-3-(3-methoxy-5-trifluoromethyl-phenylamino)-[1,2,4]triazol-1-yl]butan-2-ol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of intermediate D6 (8.356 g, 0.020 mol) and intermediate D3 (2.083 g, 0.020 mol) in ethanol (200 ml) was stirred overnight at reflux. Subsequently, the solvent was evaporated to yield intermediate D7 (S-enantiomer) as a yellow oil that was used as such in the next reaction step.

後処理

  1. temperatureat reflux
  2. customSubsequently, the solvent was evaporated

出典と根拠

ORDレコード
ord-cc7f36bb7fdf4c8aa52c4d36de27cd7f
出典データセット
uspto-grants-2013_05
特許番号
US08440701B2

反応ノート

読み込み中…