4-Phenyl-3,4-dihydro-1H-benzo[h]quinolin-2-one → HCID 66818900、化合物

HRID 2092358ノート

反応式

HRID 2092358 の反応式
[C:1]1([CH:7]2[C:16]3[C:11](=[C:12]4[CH:20]=[CH:19][CH:18]=[CH:17][C:13]4=[CH:14][CH:15]=3)[NH:10][C:9](=[O:21])[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[S]>C(O)(=O)C>[C:1]1([C:7]2[C:16]3[C:11](=[C:12]4[CH:20]=[CH:19][CH:18]=[CH:17][C:13]4=[CH:14][CH:15]=3)[NH:10][C:9](=[O:21])[CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 28297134-Phenyl-3,4-dihydro-1H-benzo[h]quinolin-2-oneHCID 5362487Sulfur2 回

生成物 1

HCID 66818900HCID 66818900、化合物収率 15%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
205 °C

実験手順

A mixture of 4-Phenyl-3,4-dihydro-1H-benzo[h]quinolin-2-one (0.55 g, 2.0 mmol) and sulfur (0.06 g, 2 mmol) was stirred at 205° C. for 0.5 hr under a nitrogen atmosphere. A second batch of sulfur (0.06 g, 2 mmol) was added and the solution stirred for 12 hr at 205° C. The product was dissolved in hot acetic acid and filtered. The clear filtrate upon cooling deposited crystals that were separated by filtration and washed with acetic acid and water followed by vacuum drying to afford the title compound (0.08 g, 0.30 mmol).

後処理

  1. stirringthe solution stirred for 12 hr at 205° C
  2. filtrationfiltered
  3. temperatureThe clear filtrate upon cooling
  4. customwere separated by filtration
  5. washwashed with acetic acid and water
  6. customdrying

出典と根拠

ORDレコード
ord-35728be90a21446bb156cd7de36402ed
出典データセット
uspto-grants-2013_05
特許番号
US08440705B2

反応ノート

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