化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → Nitro-4-(2,2,2-trifluoro-1-methyl-ethoxy)-benzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | p-Fluoronitrobenzene | HCID 9590 | — |
| 反応物 | 1,1,1-Trifluoro-2-propanol | HCID 9774 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Nitro-4-(2,2,2-trifluoro-1-methyl-ethoxy)-benzene | HCID 66577895 | — |
反応手順
A mixture of 1-fluoro-4-nitrobenzene (4.24 g, CAS Reg. No. 350-46-9), 1,1,1-trifluoro-propan-2-ol (4.56 g, CAS Reg. No. 374-01-6) and cesium carbonate (13.04 g) in CH3CN (50 mL) was heated to reflux for 10 hours. Then, the reaction mixture was cooled, acidified with conc. HCl and then distributed between ethyl acetate and water. The organic layer was separated, washed with brine and evaporated to provide the title compound (6.74 g) that was used without further purification. Rf: 0.38 (silica gel, ether/heptane 1:4).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08440710B2 |
| 出典データセット | uspto-grants-2013_05 |
| ORD ID | ord-7192b305e37e41689e71164ccf5399fb |
| 出典メモ | uspto-grants-2013_05 |