Water → 4-Amino-N,N-dimethyl-3-nitroaniline

HRID 2093042

反応式

HRID 2093042 の反応式
[CH3:1][N:2]([CH3:16])[C:3]1[CH:8]=[CH:7][C:6]([NH:9]C(=O)C)=[C:5]([N+:13]([O-:15])=[O:14])[CH:4]=1.O.[OH-].[K+]>CO>[NH2:9][C:6]1[CH:7]=[CH:8][C:3]([N:2]([CH3:16])[CH3:1])=[CH:4][C:5]=1[N+:13]([O-:15])=[O:14]

参加物

5

反応物 3

HCID 962Water2 回HCID 14797Potassium HydroxideHCID 4396139N-[4-(dimethylamino)-2-nitrophenyl]acetamide

生成物 1

HCID 27334524-Amino-N,N-dimethyl-3-nitroaniline収率 65%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of N-[4-(dimethylamino)-2-nitrophenyl]acetamide obtained in step 11 above (1.0 eq) in MeOH and water was added KOH (1.5 eq) at room temperature and stirred for 5 hrs. Water was added to the reaction mixture and the organic layer was separated, dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford crude product, which, on purification by column chromatography afforded the desired N-(4-amino-3-nitrophenyl)-N,N-dimethylamine. (Yield=65%).

後処理

  1. customthe organic layer was separated
  2. dry with materialdried over anhydrous Na2SO4
  3. concentrationconcentrated under reduced pressure
  4. customto afford crude product, which
  5. customon purification by column chromatography

出典と根拠

ORDレコード
ord-c540b97dd5a64963ac6b323b56dcc6c9
出典データセット
uspto-grants-2013_05
特許番号
US08440830B2

関連ノート

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