Diethyl Oxalate → Ethyl 3-(3-nitropyridin-4-yl)-2-oxopropanoate

HRID 2093104

反応式

HRID 2093104 の反応式
[O-]CC.[Na+].[C:5]([O:12][CH2:13][CH3:14])(=[O:11])[C:6]([O:8]CC)=O.[CH3:15][C:16]1[CH:21]=[CH:20][N:19]=[CH:18][C:17]=1[N+:22]([O-:24])=[O:23]>C1(C)C=CC=CC=1>[N+:22]([C:17]1[CH:18]=[N:19][CH:20]=[CH:21][C:16]=1[CH2:15][C:6](=[O:8])[C:5]([O:12][CH2:13][CH3:14])=[O:11])([O-:24])=[O:23]

参加物

5

反応物 3

HCID 7268Diethyl OxalateHCID 5218284-Methyl-3-nitropyridineHCID 2723922Sodium ethoxide

生成物 1

HCID 23269548Ethyl 3-(3-nitropyridin-4-yl)-2-oxopropanoate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a solution of freshly prepared sodium ethoxide was added diethyl oxalate (1.5 eq.) followed by 4-methyl-3-nitro pyridine (1 eq.) in toluene and reaction mixture was stirred overnight. It was then concentrated under reduced pressure and acidified with acetic acid to obtained red solid, which on further purification, by column chromatography provided the ethyl 3-(3-nitropyridin-4-yl)-2-oxopropanoate.

後処理

  1. concentrationIt was then concentrated under reduced pressure
  2. customto obtained red solid, which
  3. customon further purification

出典と根拠

ORDレコード
ord-833d403d014e41518e19f7df95ba7f70
出典データセット
uspto-grants-2013_05
特許番号
US08440830B2

関連ノート

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