Iodide Ion → Methyl 2'-fluoro-5'-iodo-4'-methoxy-3-methylbiphenyl-4-carboxylate

HRID 2093215ノート

反応式

HRID 2093215 の反応式
[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:10]1[CH:15]=[CH:14][C:13]([C:16]([O:18][CH3:19])=[O:17])=[C:12]([CH3:20])[CH:11]=1.[I-:21]>S([O-])([O-])(=O)=O.[Ag+2].CO>[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([I:21])=[CH:4][C:3]=1[C:10]1[CH:15]=[CH:14][C:13]([C:16]([O:18][CH3:19])=[O:17])=[C:12]([CH3:20])[CH:11]=1

参加物

5

反応物 2

HCID 30165Iodide IonHCID 57704853Methyl 2'-fluoro-4'-methoxy-3-methylbiphenyl-4-carboxylate

生成物 1

HCID 57704857Methyl 2'-fluoro-5'-iodo-4'-methoxy-3-methylbiphenyl-4-carboxylate

試薬・触媒・溶媒 2

HCID 178418844HCID 178418844、化合物触媒HCID 887Methanol溶媒

実験手順

methyl 2′-fluoro-4′-methoxy-3-methylbiphenyl-4-carboxylate (100 mg, 0.365 mmol), methanol (3 mL), iodide (93 mg, 0.366 mmol) and silver sulfate (114 mg, 0.366 mmol) were stirred at room temperature for 1.5 hours. Reaction crude was quenched by Na2SO3 (sat., aq.). Volatiles were removed from the grayish brown mixture. The pot residue was worked up with H2O/EtOAc/Na2SO4/filtration/concentration to afford the title compound. LCMS (ESI) calc.=400.00; found=400.96 (M+1)+.

後処理

  1. customReaction crude
  2. customwas quenched by Na2SO3 (sat., aq.)
  3. customVolatiles were removed from the grayish brown mixture
  4. concentrationThe pot residue was worked up with H2O/EtOAc/Na2SO4/filtration/concentration

出典と根拠

ORDレコード
ord-a7351fc43371436a854e1fd6028cd7e8
出典データセット
uspto-grants-2013_05
特許番号
US08440702B2

反応ノート

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