Ammonia → 4-Chloro-5-(trifluoromethyl)pyrimidin-2-amine

反応式

Cl[C:2]1[N:7]=[C:6]([Cl:8])[C:5]([C:9]([F:12])([F:11])[F:10])=[CH:4][N:3]=1.[NH3:13]>>[NH2:13][C:2]1[N:7]=[C:6]([Cl:8])[C:5]([C:9]([F:12])([F:11])[F:10])=[CH:4][N:3]=1

参加物

反応物 2

HCID 222Ammonia

HCID 27827742,4-Dichloro-5-(trifluoromethyl)pyrimidine

生成物 1

HCID 219231104-Chloro-5-(trifluoromethyl)pyrimidin-2-amine収率 45%

反応条件

温度: 5 °C

実験手順

With stirring, 1.0 g of 2,4-dichloro-5-(trifluoromethyl)pyrimidine, Aldrich order no. 684864, is added to a methanolic ammonia solution (ca. 8 mol of ammonia in methanol) cooled to ca. 5° C., the mixture is heated to 25° C. and stirred for 2 hours at this temperature. The mixture is concentrated by evaporation and added to water. After filtering off with suction, 0.56 g of a mixture of 4-amino-2-chloro-5-trifluoromethylpyrimidine (ca. 45%) and 2-amino-4-chloro-5-trifluoromethylpyrimidine (ca. 45%) is obtained.

後処理

temperaturethe mixture is heated to 25° C.
stirringstirred for 2 hours at this temperature
concentrationThe mixture is concentrated by evaporation
additionadded to water
filtrationAfter filtering off with suction, 0.56 g of a mixture of 4-amino-2-chloro-5-trifluoromethylpyrimidine (ca. 45%)

出典と根拠

ORDレコード: ord-fa2ad0997f144a21a66ad18d33737e02
出典データセット: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08445408B2

反応ノート

読み込み中…

参加物