Water → HCID 59406814、化合物

HRID 2093350

反応式

HRID 2093350 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:11]=[CH:12][C:13](=[O:16])[NH:14][N:15]=2)[CH:5]=[C:6]([F:9])[C:7]=1[F:8].C(=O)([O-])[O-].[Cs+].[Cs+].Br[CH2:24][C:25]1[CH:33]=[CH:32][C:28]2=[N:29][S:30][N:31]=[C:27]2[CH:26]=1.O>CN(C=O)C>[N:29]1[S:30][N:31]=[C:27]2[CH:26]=[C:25]([CH2:24][N:14]3[C:13](=[O:16])[CH:12]=[CH:11][C:10]([C:4]4[CH:5]=[C:6]([F:9])[C:7]([F:8])=[C:2]([F:1])[CH:3]=4)=[N:15]3)[CH:33]=[CH:32][C:28]=12

参加物

6

反応物 4

HCID 962WaterHCID 10796Cesium carbonateHCID 5910045-(Bromomethyl)-2,1,3-benzothiadiazoleHCID 594068096-(3,4,5-trifluorophenyl)-2H-pyridazin-3-one

生成物 1

HCID 59406814HCID 59406814、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

3.0 g (13.3 mmol) of 6-(3,4,5-trifluorophenyl)-2H-pyridazin-3-one and 4.8 g (14.4 mmol) of caesium carbonate are suspended in 250 ml of DMF, 3.0 g (13.3 mmol) of 5-(bromomethyl)2,1,3-benzothiadiazole are added, and the mixture is stirred at room temperature. After 15 h, 110 ml of water are added to the reaction mixture, which is then stirred at room temperature for 2 h. The resultant precipitate is filtered off with suction and washed with water and dried in vacuo.

後処理

  1. stirringis then stirred at room temperature for 2 h
  2. filtrationThe resultant precipitate is filtered off with suction
  3. washwashed with water
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-25b3a76f5f8b4313868866a40cd205f5
出典データセット
uspto-grants-2013_05
特許番号
US08445489B2

関連ノート

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