Phosphorus tribromide → 4-Bromo-2-(trifluoromethyl)pyrimidine
反応式
[F:1][C:2]([F:11])([F:10])[C:3]1[N:8]=[C:7](O)[CH:6]=[CH:5][N:4]=1.P(Br)(Br)[Br:13]>>[Br:13][C:7]1[CH:6]=[CH:5][N:4]=[C:3]([C:2]([F:11])([F:10])[F:1])[N:8]=1参加物
3
反応条件
- 温度
- 150 °C
実験手順
The 2-(trifluoromethyl)pyrimidin-4-ol (328 mg, 2.0 mmol) and PBr3 (0.188 mL, 2.0 mmol) were mixed and heated at 150° C. for 3 h. The reaction was cooled down and quenched with ice water, extracted with DCM (20 mL×2) to yield the titled compound. The organic phase was concentrated and crude material was purified by preparative TLC with 20% Acetone:Hexane to yield titled compound.
後処理
- temperatureThe reaction was cooled down
- customquenched with ice water
- extractionextracted with DCM (20 mL×2)
出典と根拠
- ORDレコード
- ord-bcec6bd2fc714ad48b39e26ebfcac891
- 出典データセット
- uspto-grants-2013_05
- 特許番号
- US08445499B2
反応ノート
読み込み中…