N,N,N',N'-Tetramethylethylenediamine → 4-Methyl-6-(4-(1-(5-methylpyrazin-2-yl)piperidin-4-yl)piperidin-1-yl)pyrimidine-2-carbonitrile

反応式

Cl[C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][CH:11]([CH:14]3[CH2:19][CH2:18][N:17]([C:20]4[CH:25]=[N:24][C:23]([CH3:26])=[CH:22][N:21]=4)[CH2:16][CH2:15]3)[CH2:10][CH2:9]2)[CH:5]=[C:4]([CH3:27])[N:3]=1.C1(P(C2C=CC=CC=2)CCCCCP(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[CH3:59][N:60](C)CCN(C)C.[C-]#N.[K+]>C([O-])(=O)C.[Pd+2].C([O-])(=O)C.C1(C)C=CC=CC=1>[CH3:27][C:4]1[CH:5]=[C:6]([N:8]2[CH2:13][CH2:12][CH:11]([CH:14]3[CH2:19][CH2:18][N:17]([C:20]4[CH:25]=[N:24][C:23]([CH3:26])=[CH:22][N:21]=4)[CH2:16][CH2:15]3)[CH2:10][CH2:9]2)[N:7]=[C:2]([C:59]#[N:60])[N:3]=1