Acetic Anhydride → HCID 58201210、化合物

HRID 2093554ノート

反応式

HRID 2093554 の反応式
[Cl:1][C:2]1[C:3]([CH3:11])=[N+:4]([O-])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[C:12]([O:15]C(=O)C)(=[O:14])[CH3:13]>>[C:12]([O:15][CH2:11][C:3]1[C:2]([Cl:1])=[C:7]([O:8][CH3:9])[CH:6]=[CH:5][N:4]=1)(=[O:14])[CH3:13]

参加物

3

反応物 2

HCID 7918Acetic AnhydrideHCID 13682775HCID 13682775、化合物

生成物 1

HCID 58201210HCID 58201210、化合物

実験手順

The above 3-chloro-4-methoxy-2-methylpyridin-1-oxide (890 mg) was dissolved in acetic anhydride (12 mL), and the resulting solution was then heated under reflux for 30 minutes. After leaving to cool to room temperature, the reaction solution was concentrated under reduced pressure, and the residue was then purified by silica gel chromatography (hexane-ethyl acetate), so as to obtain the title compound (576 mg) as an oily substance.

後処理

  1. temperaturethe resulting solution was then heated
  2. temperatureunder reflux for 30 minutes
  3. customAfter leaving
  4. concentrationthe reaction solution was concentrated under reduced pressure
  5. customthe residue was then purified by silica gel chromatography (hexane-ethyl acetate)

出典と根拠

ORDレコード
ord-b48613c461ed4c5aa27a5af2d23a9cd3
出典データセット
uspto-grants-2013_05
特許番号
US08445504B2

反応ノート

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