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Thionyl Chloride → 4-(Morpholin-3-on-4-yl)-3-nitro-benzoic acid chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 4-(2-Carboxymethoxy-ethylamino)-3-nitro-benzoic acid | HCID 66731908 | — |
| 触媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-(Morpholin-3-on-4-yl)-3-nitro-benzoic acid chloride | HCID 86069407 | — |
反応手順
290 mg (1.02 mmol) 4-(2-carboxymethoxy-ethylamino)-3-nitro-benzoic acid in 100 ml dichloromethane are combined with 0.186 ml (2.55 mmol) thionyl chloride and 2 drops of DMF and refluxed for one day. After evaporation of the solution i. vac. it is evaporated with toluene and the residue is further reacted without any more purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08445525B2 |
| 出典データセット | uspto-grants-2013_05 |
| ORD ID | ord-cc7afd95aa38442e8bcc227179813f27 |
| 出典メモ | uspto-grants-2013_05 |