Water → 3-Acetoxy-4-trifluoromethyl-benzoic acid

反応式

[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[C:11]([F:14])([F:13])[F:12])[C:5]([OH:7])=[O:6].O.[C:16](OC(=O)C)(=[O:18])[CH3:17]>>[C:16]([O:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[C:11]([F:12])([F:13])[F:14])[C:5]([OH:7])=[O:6])(=[O:18])[CH3:17]

参加物

反応物 3

HCID 962Water

HCID 7918Acetic Anhydride

HCID 109436363-hydroxy-4-(trifluoromethyl)benzoic Acid

生成物 1

HCID 236167943-Acetoxy-4-trifluoromethyl-benzoic acid

実験手順

3.5 g (17 mmol) of 3-hydroxy-4-trifluoromethyl-benzoic acid (prepared as described in WO 2006/128184) were dissolved in 35 ml of acetic acid anhydride and heated to reflux for 3 h. 60 ml of water were added and heating to reflux was continued for 10 min. After cooling and stirring overnight, the formed precipitate was collected by suction and dried to give 3.0 g of the title compound.