関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Oxazole | HCID 9255 | — |
| 反応物 | Tributyltin Chloride | HCID 15096 | — |
| 反応物 | (4R)-1-Boc-4-(2-propen-1-yloxy)-D-proline | HCID 67315699 | — |
| 反応物 | methyl 3-((R)-2-(methoxymethyl)pyrrolidine-1-carbonyl)-5-(oxazol-2-yl)benzoate | HCID 67316177 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-(Tri-n-butylstannyl)oxazole | HCID 15486183 | — |
反応手順
Step H (2): Preparation of methyl 3-((R)-2-(methoxymethyl)pyrrolidine-1-carbonyl)-5-(oxazol-2-yl)benzoate. To a solution of oxazole (2.0 g, 29.0 mmol) in THF (30 mL) was added n-butyl lithium (2.0 M solution in cyclohexanes, 16 mL, 31.9 mmol) at −78° C. slowly. The reaction mixture was stirred at −78° C. for 1.2 h, then tributylstannyl chloride (5.0 g, 15.4 mmol) was added. The reaction mixture was warmed up to rt over 3 h. Hexanes (200 mL) was added and the mixture was washed with H2O, dried over Na2SO4 and concentrated under vacuum to give 5.6 g of the 2-(tributylstannyl)oxazole ready for use.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07745470B2 |
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| 出典データセット | uspto-grants-2010_06 |
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| ORD ID | ord-03d30734f4e146ad9f6aeb1b2e8c3cb4 |
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| 出典メモ | uspto-grants-2010_06 |
|---|
