Dicyclohexylcarbodiimide → Benzoic acid, 3-amino-5-nitro-, ethyl ester

HRID 2095101

反応式

HRID 2095101 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=1)[C:5]([OH:7])=[O:6].[CH2:14]1CCC(N=C=NC2CCCCC2)C[CH2:15]1>CCO>[CH2:14]([O:6][C:5](=[O:7])[C:4]1[CH:8]=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=[C:2]([NH2:1])[CH:3]=1)[CH3:15]

参加物

4

反応物 2

HCID 10868DicyclohexylcarbodiimideHCID 2393423-Amino-5-nitrobenzoic acid

生成物 1

HCID 826201Benzoic acid, 3-amino-5-nitro-, ethyl ester

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

3-Amino-5-nitrobenzoic acid (910 mg, 5.0 mmol) was dissolved in EtOH (25 mL). DCC (1.51 g, 7.3 mmol) was added, and the mixture was stirred under reflux overnight. The solid precipitation was filtered off and the filtrate was evaporated. The residue was triturated in the solvent mixture ether:hexane:ethyl acetate, 5:5:1. The title compound was isolated as a fine light yellow powder (0.9 g, 85.7%).

後処理

  1. temperatureunder reflux overnight
  2. customThe solid precipitation
  3. filtrationwas filtered off
  4. customthe filtrate was evaporated
  5. customThe residue was triturated in the solvent mixture ether

出典と根拠

ORDレコード
ord-f515d0739ec546ff8cbd60c893927959
出典データセット
uspto-grants-2013_05
特許番号
US08445694B2

関連ノート

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