Potassium Hydroxide → 6-Aminoquinazoline

HRID 2095157ノート

反応式

HRID 2095157 の反応式
Cl[Sn]Cl.[N+:4]([C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[CH:12][N:11]=[CH:10]2)([O-])=O.[OH-].[K+]>Cl>[NH2:4][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[CH:12][N:11]=[CH:10]2

参加物

5

反応物 3

HCID 14797Potassium HydroxideHCID 24479Stannous ChlorideHCID 6002116-Nitroquinazoline

生成物 1

HCID 5892886-Aminoquinazoline

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒2 回

実験手順

SnCl2 (8.5 g) dissolved in 8.5 mL of conc. HCl was added to the solution of 6-nitroquinazoline in 42.5 mL of 6 N HCl at 0° C. The reaction mixture was neutralized with KOH 10 minutes later and then extracted with diethyl ether (Et2O) and EtOAc. The product 6-aminoquinazoline was obtained (0.67 g) after the removal of the solvent.

後処理

  1. extractionextracted with diethyl ether (Et2O) and EtOAc

出典と根拠

ORDレコード
ord-c28f91cc0c7247d8b3fb3eb3b67f240b
出典データセット
uspto-grants-2013_05
特許番号
US08445694B2

反応ノート

読み込み中…