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2,6-Lutidine → HCID 86652692、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,6-Lutidine | HCID 7937 | — |
| 反応物 | Ethyl 2-bromopropionate | HCID 79040 | — |
| 反応物 | 3,4-Bis(trifluoromethyl)aniline | HCID 1548579 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | HCID 86652692 | HCID 86652692 | 49% |
反応手順
In analogy to intermediate 40B, 3,4-bis(trifluoromethyl)aniline and ethyl 2-bromopropionate with 2,6-lutidine were heated for 20 h at 82° C., diluted with acetonitrile and treated with 1 equivalent of ethyl 2-bromopropionate and 2,6-lutidine and refluxed for 2 days, treated again with 1 equivalent of ethyl 2-bromopropionate and 2,6-lutidine and continued to reflux for 2 days. Workup and purification by flash silica gel column (n-heptane/ethyl acetate 9:1 to 2:1) yielded 49% of the titled compound as yellow oil. MS: 328.08 (M−H−).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08445674B2 |
| 出典データセット | uspto-grants-2013_05 |
| ORD ID | ord-6f8ee845b05c404b896f0b54c7f716e9 |
| 出典メモ | uspto-grants-2013_05 |