化工社化工社 化学情報印刷レポート · 研究参考用
(R)-2-(3,4-Dichloro-phenylamino)-propionic acid → 3-(3-Chloro-4-trifluoromethyl-phenylamino)-propionic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (R)-2-(3,4-Dichloro-phenylamino)-propionic acid | HCID 182146 | — |
| 反応物 | tert-Butyl 3-bromopropionate | HCID 256128 | — |
| 反応物 | 4-Bromo-2-chlorobenzotrifluoride | HCID 20269848 | — |
| 生成物 | 3-(3-Chloro-4-trifluoromethyl-phenylamino)-propionic acid tert-butyl ester | HCID 67074412 | 53% |
反応手順
In analogy to the procedure described for intermediate 31, 4-bromo-2-chloro-1-trifluoromethyl-benzene and tert-butyl 3-bromopropionate gave the title compound in 53% yield as yellow oil. MS: 323 (M+, Cl).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08445674B2 |
| 出典データセット | uspto-grants-2013_05 |
| ORD ID | ord-03b14744d21f4c648d78db792fac9c37 |
| 出典メモ | uspto-grants-2013_05 |