Methyl morpholine oxide → HCID 66697339、化合物

HRID 2096796ノート

反応式

HRID 2096796 の反応式
C[N+]1([O-])CCOCC1.[Br:9][C:10]1[CH:15]=[CH:14][C:13]([CH:16]([CH3:31])[CH:17]([C:19]2[CH:30]=[CH:29][C:22]3[N:23]([CH3:28])[C:24](=[O:27])[N:25]([CH3:26])[C:21]=3[CH:20]=2)[OH:18])=[C:12]([Cl:32])[CH:11]=1>C(Cl)Cl.[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[Br:9][C:10]1[CH:15]=[CH:14][C:13]([CH:16]([CH3:31])[C:17]([C:19]2[CH:30]=[CH:29][C:22]3[N:23]([CH3:28])[C:24](=[O:27])[N:25]([CH3:26])[C:21]=3[CH:20]=2)=[O:18])=[C:12]([Cl:32])[CH:11]=1

参加物

5

反応物 2

HCID 82029Methyl morpholine oxideHCID 67546932HCID 67546932、化合物

生成物 1

HCID 66697339HCID 66697339、化合物収率 97.2%

試薬・触媒・溶媒 2

HCID 178419074HCID 178419074、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

4-Methyl-morpholine-4-oxide (280 mg) and tetrapropylammonium perruthenate (36 mg) were added to a solution of 5-[2-(4-bromo-2-chloro-phenyl)-1-hydroxy-propyl]-1,3-dimethyl-1,3-dihydro-benzoimidazol-2-one (424 mg) in DCM (5 ml) with 3 A molecular sieves. The mixture was stirred for 3 h at room temperature, filtered over SiO2 (10 g) and concentrated to give the title compound (410 mg) as a white foam. MS (m/e)=409.1 [M+H+].

後処理

  1. filtrationfiltered over SiO2 (10 g)
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-95c2a17e31e64159bb6f44f69cf4c82b
出典データセット
uspto-grants-2013_05
特許番号
US08450313B2

反応ノート

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