4-Cyano-3,5-dimethylbenzoic acid → 4-[2-(2-Chloro-4-methoxy-phenyl)-acetyl]-2,6-dimethyl-benzonitrile

反応式

CO[C:3](=[O:14])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:6]=1[Cl:13].[C:15]([C:17]1[C:25]([CH3:26])=[CH:24][C:20](C(O)=O)=[CH:19][C:18]=1[CH3:27])#[N:16]>>[Cl:13][C:6]1[CH:7]=[C:8]([O:11][CH3:12])[CH:9]=[CH:10][C:5]=1[CH2:4][C:3]([C:20]1[CH:24]=[C:25]([CH3:26])[C:17]([C:15]#[N:16])=[C:18]([CH3:27])[CH:19]=1)=[O:14]

参加物

反応物 2

HCID 139978794-Cyano-3,5-dimethylbenzoic acid

HCID 573835072-Chloro-4-methoxyphenylacetic acid methylester

生成物 1

HCID 666971094-[2-(2-Chloro-4-methoxy-phenyl)-acetyl]-2,6-dimethyl-benzonitrile

実験手順

The title compound was prepared in analogy to Example 138, steps 1 and 2, from (2-chloro-4-methoxy-phenyl)-acetic acid methyl ester and 4-cyano-3,5-dimethyl-benzoic acid (CAS [90924-01-0]). Orange solid. MS (m/e, ISP neg. ion)=312.1 [M−H+].

出典と根拠

ORDレコード: ord-8373640c96934b8cbb4714022bd1083d
出典データセット: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08450313B2

反応ノート

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