Sulfuric Acid → 2-Fluoro-3-iodobenzoic acid
反応式
[F:1][C:2]1[C:9]([I:10])=[CH:8][CH:7]=[CH:6]C=1C#N.S(=O)(=O)(O)[OH:12].[O:16]1[CH2:21][CH2:20]OCC1>>[F:1][C:2]1[C:9]([I:10])=[CH:8][CH:7]=[CH:6][C:20]=1[C:21]([OH:16])=[O:12]参加物
4
反応条件
- 温度
- 115 °C
実験手順
A mixture of 2-fluoro-3-iodobenzonitrile (preparation 22a, 5.00 g, 20.2 mmol), dioxane (16 mL) and sulphuric acid (25 mL) was heated to 115° C. After 4 hours, the mixture was cooled and filtered. Water was added to the filtrate and the mixture was extracted with ethyl acetate. The organic layer was dried (MgSO4) and evaporated to give the title compound (4.42 g, 82%) as a solid.
後処理
- temperaturethe mixture was cooled
- filtrationfiltered
- additionWater was added to the filtrate
- extractionthe mixture was extracted with ethyl acetate
- dry with materialThe organic layer was dried (MgSO4)
- customevaporated
出典と根拠
- ORDレコード
- ord-aa40a567225948ffbedee37bd3881c95
- 出典データセット
- uspto-grants-2013_05
- 特許番号
- US08450341B2
反応ノート
読み込み中…