2-Fluoro-3-iodobenzyl alcohol → 2-Fluoro-3-iodobenzaldehyde
反応式
[F:1][C:2]1[C:7]([I:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][OH:10]>ClCCl.[O-2].[Mn+4].[O-2]>[F:1][C:2]1[C:7]([I:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:9]=[O:10]参加物
4
反応条件
- 温度
- 50 °C
実験手順
Manganese (IV) oxide (15.40 g, 177 mmol) was added portionwise to a stirred solution of (2-fluoro-3-iodophenyl)methanol (preparation 22c, 4.03 g, 16 mmol) in dichloromethane (140 mL) and the mixture was stirred at 50° C. After 3 hours, the mixture was filtered through Celite® and the solvent was evaporated to give the title compound (2.10 g, 53%) as a white solid.
後処理
- filtrationthe mixture was filtered through Celite®
- customthe solvent was evaporated
出典と根拠
- ORDレコード
- ord-1d74945dfe634e5d9ed8810de5f2c9fc
- 出典データセット
- uspto-grants-2013_05
- 特許番号
- US08450341B2
反応ノート
読み込み中…