2-(3-Cyclopropoxy-4-difluoromethoxyphenyl)-3-propyl-5-(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one → 2-(3-Cyclopropoxy-4-difluoromethoxyphenyl)-3-phenethyl-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one
反応式
[CH:1]1([O:4][C:5]2[CH:6]=[C:7]([C:15]3[NH:32][C:18]4[CH:19]=[N:20][N:21](COCC[Si](C)(C)C)[C:22](=[O:23])[C:17]=4[C:16]=3[CH2:33][CH2:34][C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)[CH:8]=[CH:9][C:10]=2[O:11][CH:12]([F:14])[F:13])[CH2:3][CH2:2]1.C1(OC2C=C(C3NC4C=NN(COCC[Si](C)(C)C)C(=O)C=4C=3CCC)C=CC=2OC(F)F)CC1>>[CH:1]1([O:4][C:5]2[CH:6]=[C:7]([C:15]3[NH:32][C:18]4[CH:19]=[N:20][NH:21][C:22](=[O:23])[C:17]=4[C:16]=3[CH2:33][CH2:34][C:35]3[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=3)[CH:8]=[CH:9][C:10]=2[O:11][CH:12]([F:13])[F:14])[CH2:3][CH2:2]1参加物
3
反応物 2
生成物 1
実験手順
Reaction was carried out in the same manner as in Example 6-(c) except for using 364 mg (0.641 mmol) of 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-phenethyl-5-(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one obtained in Example 21-(b) in place of 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-5-(2-trimethylsilylethoxymethyl)-3-propyl-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one. After completion of the reaction, the solid was collected by filtration from the reaction suspension and washed with 1,4-dioxane. To the obtained solid were added methanol and 28% aqueous ammonia, and the mixture was stirred at room temperature for 16 hours. Then, water was added to the solution, and the precipitated solid was collected by filtration. The obtained solid was washed with water and dried under reduced pressure to obtain 224 mg of the title compound as a white solid. (Yield: 80%)