2-(isoquinolin-5-yl)acetic acid hydrochloride → HCID 52948593、化合物
反応式
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]1[N:8]=[CH:9][S:10][C:11]=1[NH2:12].Cl.[CH:14]1[C:23]2[C:18](=[C:19]([CH2:24][C:25](O)=[O:26])[CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16][N:15]=1>>[CH:14]1[C:23]2[C:18](=[C:19]([CH2:24][C:25]([NH:12][C:11]3[S:10][CH:9]=[N:8][C:7]=3[C:2]3[CH:3]=[N:4][CH:5]=[CH:6][N:1]=3)=[O:26])[CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16][N:15]=1参加物
3
実験手順
The crude 4-(pyrazin-2-yl)thiazol-5-amine was coupled with 2-(isoquinolin-5-yl)acetic acid hydrochloride using procedure A and was purified by HPLC purified to afford desired material as a white trifluoroacetic acid salt (107 mg). Method [8]: rt=3.71 min; 1H NMR (CDCl3) δ12.16 (s, 1H), 9.80 (s, 1H), 9.48 (d, J=1.2 Hz, 1H), 8.64 (d, J=6.4 Hz, 1H), 8.47 (s, 1H), 8.45 (d, J=2.7 Hz, 1H), 8.39 (d, J=8.5 Hz, 1H), 8.31 (d, J=6.5 Hz, 1H), 8.15 (d, J=7.2 Hz, 1H), 8.10-7.98 (m, 2H), 4.45 (s, 2H); MH+ 348.0.
後処理
- customwas purified by HPLC
- custompurified
出典と根拠
- ORDレコード