1H-Indol-2-ylboronic acid → HCID 59593001、化合物

関与物質

反応手順

2-Methyl-4-morpholin-4-yl-thieno[3,2-d]pyrimidine-6-carboxylic acid (2-methoxyethyl)-amide was reacted with indole boronic acid in general procedure A. Purification on silica yielded 189. NMR: 400MHz; CDCl3 3.44 (3H, s); 3.60 (2H, m); 3.70 (2H, m); 3.92 (4H, t, J=4.8 Hz); 4.15 (4H,t,J=4.8Hz); 6.74 (1H,br t); 7.30 (1H,d,J=7.8Hz); 7.35 (1H,m); 7.52 (1H,d,J=8.0Hz); 7.57 (1H,s); 7.82 (1H,s); 8.2 0(1H,d,J=7.4Hz); 8.30 (1H,br s). MS: (ESI+) M+H (438)

情報源と証拠