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N-bromobutanimide → 4-amino-7-bromo-2,3-dihydro-1H-isoindole-1,3-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | 1H-Isoindole-1,3(2H)-dione, 4-amino- | HCID 72914 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-amino-7-bromo-2,3-dihydro-1H-isoindole-1,3-dione | HCID 68489089 | 74.5% |
反応手順
3-Aminophthalimide (2.00 g, 12.3 mmol) was dissolved in methanol (200 mL), and the solution was added with N-bromosuccinimide (2.19 g, 12.3 mmol), followed by stirring at room temperature for 50 minutes. The obtained solid was collected by filtration and washed with methanol to obtain 3-amino-6-bromophthalimide (2.21 g, yield 74%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745641B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-71a5479c3a334ee98e9d5b229fda0e3e |
| 出典メモ | uspto-grants-2010_06 |