N-bromobutanimide → 4-amino-7-bromo-2,3-dihydro-1H-isoindole-1,3-dione

HRID 20993

反応式

HRID 20993 の反応式
[NH2:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:4]2[C:5]([NH:7][C:8](=[O:9])[C:3]=12)=[O:6].[Br:13]N1C(=O)CCC1=O>CO>[NH2:1][C:2]1[CH:12]=[CH:11][C:10]([Br:13])=[C:4]2[C:5]([NH:7][C:8](=[O:9])[C:3]=12)=[O:6]

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 729141H-Isoindole-1,3(2H)-dione, 4-amino-

生成物 1

HCID 684890894-amino-7-bromo-2,3-dihydro-1H-isoindole-1,3-dione収率 74.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

3-Aminophthalimide (2.00 g, 12.3 mmol) was dissolved in methanol (200 mL), and the solution was added with N-bromosuccinimide (2.19 g, 12.3 mmol), followed by stirring at room temperature for 50 minutes. The obtained solid was collected by filtration and washed with methanol to obtain 3-amino-6-bromophthalimide (2.21 g, yield 74%).

後処理

  1. filtrationThe obtained solid was collected by filtration
  2. washwashed with methanol

出典と根拠

ORDレコード
ord-71a5479c3a334ee98e9d5b229fda0e3e
出典データセット
uspto-grants-2010_06
特許番号
US07745641B2

関連ノート

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