[3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-carbamic acid, 1,1-dimethylethyl ester → 3-(5-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzenamine

HRID 2099456ノート

反応式

HRID 2099456 の反応式
[CH3:1][C:2]1[N:6]([C:7]2[CH:8]=[C:9]([NH:17]C(=O)OC(C)(C)C)[CH:10]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:12]=2)[CH:5]=[N:4][CH:3]=1.CC1N(C2C=C(NC(=O)OC(C)(C)C)C=C(C(F)(F)F)C=2)C=CN=1>>[CH3:1][C:2]1[N:6]([C:7]2[CH:12]=[C:11]([C:13]([F:16])([F:14])[F:15])[CH:10]=[C:9]([NH2:17])[CH:8]=2)[CH:5]=[N:4][CH:3]=1

参加物

3

反応物 2

HCID 86605432[3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-carbamic acid, 1,1-dimethylethyl esterHCID 86606803[3-(5-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-carbamic acid, 1,1-dimethylethyl ester

生成物 1

HCID 591542313-(5-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzenamine

実験手順

Utilising the procedure described in Example 91d, but employing [3-(5-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-carbamic acid, 1,1-dimethylethyl ester (Example 93c) in lieu of [3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-carbamic acid, 1,1-dimethylethyl ester, afforded the title compound as a colourless crystalline solid, m.p. 131-133° C.

出典と根拠

ORDレコード
ord-ae7aaaf27542495c90175d17c9f03c1e
出典データセット
uspto-grants-2009_08
特許番号
US07569566B2

反応ノート

読み込み中…