Dibutyltin dichloride → HCID 178499286、化合物

HRID 2099648

反応式

HRID 2099648 の反応式
[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([C:11]2[CH2:16][CH2:15][C:14]([CH3:18])([CH3:17])[CH2:13][CH:12]=2)=[CH:8][C:9]=1[NH2:10])=[O:4].[N:19]1([CH:24]([CH2:30][CH3:31])[CH2:25][CH2:26][C:27](=O)C)[CH:23]=[N:22][CH:21]=[N:20]1.C([Sn](Cl)(Cl)CCCC)CCC.C1([SiH3])C=CC=CC=1>>[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([C:11]2[CH2:16][CH2:15][C:14]([CH3:18])([CH3:17])[CH2:13][CH:12]=2)=[CH:8][C:9]=1[NH:10][C@H:27]1[CH2:26][CH2:25][C@H:24]([N:19]2[CH:23]=[N:22][CH:21]=[N:20]2)[CH2:30][CH2:31]1)=[O:4]

参加物

5

反応物 4

HCID 12688Dibutyltin dichlorideHCID 12752PhenylsilaneHCID 577954353-Amino-5-(4,4-dimethyl-cyclohex-1-enyl)-thiophene-2-carboxylic acid methyl esterHCID 672786375-[1,2,4]Triazol-1-yl-heptan-2-one

生成物 1

HCID 178499286HCID 178499286、化合物収率 81.4%

実験手順

Reductive amination of 3-amino-5-(4,4-dimethyl-cyclohex-1-enyl)-thiophene-2-carboxylic acid methyl ester (0.630 g, 2.37 mmol) and 5-[1,2,4]triazol-1-yl-heptan-2-one (0.560 g, 3.39 mmol) was performed under the same conditions previously described (example 3, step I) using dibutyltin dichloride and phenylsilane to give 5-(4,4-Dimethyl-cyclohex-1-enyl)-3-(trans-4-[1,2,4]triazol-1-yl-cyclohexylamino)-thiophene-2-carboxylic acid methyl ester (0.800 g, 64%).

出典と根拠

ORDレコード
ord-217bf567a3944959a8e51a5aa8c25382
出典データセット
uspto-grants-2009_08
特許番号
US07569600B2

関連ノート

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