Cesium carbonate → tert-Butyl 1-(1-((2-chloro-6-methylpyridin-4-yl)methyl)-1H-imidazol-2-yl)-2-(7-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazol-5-yl)ethylcarbamate
反応式
[C:1]([O:5][C:6](=[O:33])[NH:7][CH:8]([C:28]1[NH:29][CH:30]=[CH:31][N:32]=1)[CH2:9][C:10]1[CH:18]=[C:17]([CH3:19])[C:16]2[C:12](=[CH:13][N:14]([CH2:20][O:21][CH2:22][CH2:23][Si:24]([CH3:27])([CH3:26])[CH3:25])[N:15]=2)[CH:11]=1)([CH3:4])([CH3:3])[CH3:2].[Cl:34][C:35]1[CH:40]=[C:39]([CH2:41]Cl)[CH:38]=[C:37]([CH3:43])[N:36]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C)C=O>[Cl:34][C:35]1[CH:40]=[C:39]([CH2:41][N:32]2[CH:31]=[CH:30][N:29]=[C:28]2[CH:8]([NH:7][C:6](=[O:33])[O:5][C:1]([CH3:4])([CH3:2])[CH3:3])[CH2:9][C:10]2[CH:18]=[C:17]([CH3:19])[C:16]3[C:12](=[CH:13][N:14]([CH2:20][O:21][CH2:22][CH2:23][Si:24]([CH3:25])([CH3:27])[CH3:26])[N:15]=3)[CH:11]=2)[CH:38]=[C:37]([CH3:43])[N:36]=1参加物
5
反応物 3
生成物 1
試薬・触媒・溶媒 1
実験手順
tert-Butyl-1-(1H-imidazol-2-yl)-2-(7-methyl-2-[{2-[trimethylsilyl]ethoxy}methyl]-2H-indazol-5-yl)ethylcarbamate (0.1 g, 0.212 mmol), 2-chloro-4-(chloromethyl)-6-methylpyridine (39.0 mg, 0.222 mmol, 1.05 equiv), and cesium carbonate (0.21 g, 0.64 mmol) were combined in dimethylformamide (2.0 mL). After stirring at room temperature for 16 h, the solvents were removed and the residue purified by column chromatography to afford 0.1 g (77%). Mass spec.: 611.21 (MH)+.
後処理
- customthe solvents were removed
- customthe residue purified by column chromatography
- customto afford 0.1 g (77%)
出典と根拠
- ORDレコード
- ord-e3f201f8d5514f7ebef75b755a0d0313
- 出典データセット
- uspto-grants-2009_08
- 特許番号
- US07569578B2
反応ノート
読み込み中…