Hydrochloric Acid → 1-(4-Hydroxyphenyl)-2-methoxyethan-1-one
反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1)=[O:4].[CH3:12][O-:13].[Na+].Cl>CO>[OH:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][O:13][CH3:12])=[CH:6][CH:7]=1参加物
5
実験手順
3.0 g of 2-bromo-1-(4-hydroxy-phenyl)-ethanone in 25 ml of methanol are added dropwise in the course of 10 minutes to a solution of 7.5 g of sodium methanolate in 80 ml of methanol. Stirring is then carried out at 60° C. for 45 minutes. The reaction mixture is cooled, poured into dilute hydrochloric acid and extracted with ethyl acetate. After concentration of the organic phases and crystallisation from diethyl ether, 1-(4-hydroxy-phenyl)-2-methoxyethanone is obtained. 1H-NMR (CDCl3) 300 MHz: 3.50 (s, 3H), 4.70 (s, 2H), 6.62 (s, 1H), 6.91 (d, 2H), 7.89 (d, 2H)
後処理
- temperatureThe reaction mixture is cooled
- extractionextracted with ethyl acetate
- customAfter concentration of the organic phases and crystallisation from diethyl ether
出典と根拠
- ORDレコード
- ord-09684e6c5933432a8d839d38224fb707
- 出典データセット
- uspto-grants-2009_08
- 特許番号
- US07569727B2
反応ノート
読み込み中…