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4-Acetylmorpholine → 2-(4-morpholinyl)-8-phenoxy-4H-1-benzopyran-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Acetylmorpholine | HCID 15543 | — |
| 反応物 | Trifluoromethanesulfonic anhydride | HCID 67749 | — |
| 反応物 | Methyl 3-phenoxy-2-hydroxybenzoate | HCID 22263553 | — |
| 生成物 | 2-(4-morpholinyl)-8-phenoxy-4H-1-benzopyran-4-one | HCID 9880248 | 27.8% |
反応手順
Condensation of the lithium enolate of N-acetyl morpholine (0.21 g, 1.6 mmol) with methyl 3-phenoxy-2-hydroxybenzoate (0.25 g, 1.0 mmol) followed by cyclodehydration with trifluoromethanesulfonic anhydride (0.60 ml, 3.6 mmol) as described above yielded TGX-134 as an off-white solid (0.090 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07572791B2 |
| 出典データセット | uspto-grants-2009_08 |
| ORD ID | ord-3a076d09793d4c4cac5d67b2a3306c58 |
| 出典メモ | uspto-grants-2009_08 |