関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 反応物 | 3-Bromo-2-chloro-4-(4-chlorophenyl)pyridine | HCID 57799367 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-Bromo-4-(4-chlorophenyl)-2-hydrazinylpyridine | HCID 57799454 | — |
反応手順
A mixture of 3-bromo-2-chloro-4-(4-chlorophenyl)pyridine (10 g, 33 mmol), pyridine (50 mL) and hydrazine monohydrate (4.8 g, 96 mmol) was heated to 120° C. for 16 h. After cooling to room temperature, water (300 mL) was added, which caused solid desired product to precipitate. This was filtered, washed with water (2×50 mL), and dried to obtain the title compound as a pale yellow solid (6 g), which was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07572808B2 |
|---|
| 出典データセット | uspto-grants-2009_08 |
|---|
| ORD ID | ord-b19a41e389964ee2b2d4ca5d7f604812 |
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| 出典メモ | uspto-grants-2009_08 |
|---|
