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HRID 2101719作成日：2026年10月26日
1-Aminopiperidine → N-(Piperidin-1-yl)-4-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-1-methylimidazole-2-carboxamide
https://huagongshe.com/reaction/2101719
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Aminopiperidine | HCID 16658 | — |
| 反応物 | Ethyl 4-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-1-methylimidazole-2-carboxylate | HCID 22066075 | — |
| 生成物 | N-(Piperidin-1-yl)-4-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-1-methylimidazole-2-carboxamide | HCID 10183243 | — |
反応手順
A mixture of ethyl 4-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-1-methylimidazole-2-carboxylate (50 mg, 0.125 mmol) from Step D in neat 1-aminopiperidine (1 mL) was heated at 90° C. for 72 hr. Most of the amine was evaporated under a stream of nitrogen and the residue was purified by Prep TLC (2×1 mm, silica) (40% ethyl acetate in hexanes to afford the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07572785B2 |
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| 出典データセット | uspto-grants-2009_08 |
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| ORD ID | ord-32a9b6ea237a4719b9ecba72c5ce1b06 |
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| 出典メモ | uspto-grants-2009_08 |
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