N,N-Dimethylformamide--water (1/1) → 3-Cyclopropyl-3-(4-hydroxyphenyl)propanoic acid
反応式
[CH:1]1([CH:4]([C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=2)[CH:5]2C(=O)OC(C)(C)[O:7][C:6]2=[O:14])[CH2:3][CH2:2]1.CN(C=O)C.O>CCOC(C)=O>[CH:1]1([CH:4]([C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=2)[CH2:5][C:6]([OH:14])=[O:7])[CH2:3][CH2:2]1参加物
4
実験手順
A solution of 21.2 in 10:1 DMF/water (48 mL) was stirred overnight at 90° C. The mixture was cooled to room temperature, diluted with EtOAc, washed with 1 N HCl and brine, dried (MgSO4), and concentrated to afford 21.3. The crude product was used without further purification.
後処理
- washwashed with 1 N HCl and brine
- dry with materialdried (MgSO4)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-c9b43c88a22a4f5db78d5fad178d2fde
- 出典データセット
- uspto-grants-2009_08
- 特許番号
- US07572934B2
反応ノート
読み込み中…