Methanol → Methyl 3-cyclopropyl-3-(4-hydroxyphenyl)propanoate

HRID 2101782ノート

反応式

HRID 2101782 の反応式
[CH:1]1([CH:4]([C:9]2[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=2)[CH2:5][C:6]([OH:8])=[O:7])[CH2:3][CH2:2]1.[CH3:16]O>S(=O)(=O)(O)O.CCOC(C)=O>[CH:1]1([CH:4]([C:9]2[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=2)[CH2:5][C:6]([O:8][CH3:16])=[O:7])[CH2:3][CH2:2]1

参加物

5

反応物 2

HCID 887MethanolHCID 576725253-Cyclopropyl-3-(4-hydroxyphenyl)propanoic acid

生成物 1

HCID 57672485Methyl 3-cyclopropyl-3-(4-hydroxyphenyl)propanoate収率 84%

試薬・触媒・溶媒 2

HCID 1118Sulfuric Acid触媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 21.3 (2.4 g, 12 mmol) in MeOH (25 mL) was added five drops of sulfuric acid. The mixture was stirred overnight at reflux, cooled to room temperature, diluted with EtOAc, washed with water and brine, dried over MgSO4, filtered, and concentrated. The crude product was chromatographed on silica gel (0-25% EtOAc/hexane) to afford 21.4 (2.2 g, 84%) as a colorless oil.

後処理

  1. temperatureat reflux
  2. washwashed with water and brine
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customThe crude product was chromatographed on silica gel (0-25% EtOAc/hexane)

出典と根拠

ORDレコード
ord-a6c8a009d67146f9a794181615e75689
出典データセット
uspto-grants-2009_08
特許番号
US07572934B2

反応ノート

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