Bromine → HCID 57800275、化合物
反応式
[Cl:1][C:2]1[C:3]([CH3:15])=[C:4]([NH:8][C:9](=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11])[CH:5]=[CH:6][CH:7]=1.[Br:16]Br>CC(O)=O>[Br:16][C:7]1[CH:6]=[CH:5][C:4]([NH:8][C:9](=[O:14])[C:10]([CH3:11])([CH3:12])[CH3:13])=[C:3]([CH3:15])[C:2]=1[Cl:1]参加物
4
実験手順
N-(3-Chloro-2-methylphenyl)-2,2-dimethylpropanamide (0.5 g, 2.2 mmol) and bromine (1.4 g, 8.8 mmol) were combined in AcOH (25 mL) at rt for 2 h. The residue resulting from concentration was purified by flash chromatography (20-60% EtOAc-hexanes gradient) to afford the title compound: MS (ES) m/z 305 (M+1).
後処理
- customThe residue resulting from concentration
- customwas purified by flash chromatography (20-60% EtOAc-hexanes gradient)
出典と根拠
- ORDレコード
- ord-962a54a146a14db48b09f43b8fdad9d4
- 出典データセット
- uspto-grants-2009_08
- 特許番号
- US07572820B2
反応ノート
読み込み中…