Triethylamine → 918525-01-6

HRID 2102739ノート

反応式

HRID 2102739 の反応式
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6](C(O)=O)=[CH:5][N:4]=1.C1(P(N=[N+]=[N-])(C2C=CC=CC=2)=[O:19])C=CC=CC=1.C([N:31]([CH2:34]C)CC)C>C1(C)C=CC=CC=1>[N:31]([C:6]1[CH:10]=[CH:11][C:3]([O:2][CH3:1])=[N:4][CH:5]=1)=[C:34]=[O:19]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 199401P,P-Diphenylphosphinic azideHCID 5924996-Methoxynicotinic acid

生成物 1

HCID 14599989918525-01-6

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

実験手順

To a suspension of 6-methoxy-nicotinic acid (0.459 g, 3 mmol) (Matrix) in toluene (15 mL) was added diphenylphosphoryl azide (0.958 g, 3.5 mmol) (Aldrich), followed by the addition of triethylamine (0.35 g, 3.6 mmol) (Aldrich). The mixture was stirred at room temperature for 30 minutes and the mixture became clear. Then the mixture was heated at 80° C. for 2 hours. The mixture was cooling down to room temperature to give crude 5-isocyanato-2-methoxy-pyridine as 0.2 M solution of toluene and used for the next step without further purification.

後処理

  1. temperatureThen the mixture was heated at 80° C. for 2 hours
  2. temperatureThe mixture was cooling down to room temperature

出典と根拠

ORDレコード
ord-1be6e55c0ce84a2594c09722f7cd59d3
出典データセット
uspto-grants-2009_08
特許番号
US07576082B2

反応ノート

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