Isopropanol → HCID 45117314、化合物
反応式
[CH3:1][C:2]([CH3:14])([CH3:13])[C:3]#[C:4][C:5]1[N:10]=[CH:9]C(C#N)=[CH:7][N:6]=1.[OH-:15].[K+].[CH:17]([OH:20])([CH3:19])C>O>[CH3:1][C:2]([CH3:14])([CH3:13])[C:3]#[C:4][C:5]1[N:10]=[CH:9][C:19]([C:17]([OH:20])=[O:15])=[CH:7][N:6]=1参加物
5
実験手順
A mixture 2-(3,3-dimethylbut-1-ynyl)pyrimidine-5-carbonitrile (1.0 g, 0.005 mol) and potassium hydroxide (2.8 g, 0.05 mol) in isopropanol (40 mL) and water (10 mL) was heated at reflux for three hours. The mixture was allowed to cool to room temperature and concentrated under vacuum. Water (200 mL) was added and the mixture was cooled to 0° C., then conc. HCl was added until a pH of 6 was obtained. The resulting off-white precipitate was collected by filtration and washed with water to give the product as a solid. m/z=205 (M+1).
後処理
- temperatureat reflux for three hours
- concentrationconcentrated under vacuum
- additionWater (200 mL) was added
- temperaturethe mixture was cooled to 0° C.
- additionconc. HCl was added until a pH of 6
- customwas obtained
- filtrationThe resulting off-white precipitate was collected by filtration
- washwashed with water
出典と根拠
- ORDレコード
- ord-61ba0ab9033d45c8814379103ca02c56
- 出典データセット
- uspto-grants-2009_08
- 特許番号
- US07576099B2
反応ノート
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