Sodium Chloride → N,N-Dimethyl-N'-(5-bromothiophene-2-sulfonyl)formamidine

HRID 2103615ノート

反応式

HRID 2103615 の反応式
CO[CH:3]([N:6]([CH3:8])[CH3:7])OC.[Br:9][C:10]1[S:14][C:13]([S:15]([NH2:18])(=[O:17])=[O:16])=[CH:12][CH:11]=1.[Cl-].[Na+]>CN(C=O)C>[CH3:7][N:6]([CH:3]=[N:18][S:15]([C:13]1[S:14][C:10]([Br:9])=[CH:11][CH:12]=1)(=[O:17])=[O:16])[CH3:8]

参加物

5

反応物 3

HCID 5234Sodium ChlorideHCID 78373Dimethylformamide dimethyl acetalHCID 12413045-Bromo-2-thiophenesulfonamide

生成物 1

HCID 54319951N,N-Dimethyl-N'-(5-bromothiophene-2-sulfonyl)formamidine収率 114.1%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Add dimethoxymethyl-dimethyl-amine (1.05 mL, 7.66 mmol) to a solution-of 5-bromo-thiophene-2-sulfonic acid amide (1.8 g, 7.43 mmol) in DMF (3 mL) at r.t. for 16 h. Pour reaction mixture into saturated sodium chloride, extract with ethylacetate. Wash combined organic layers with water, dry over sodium sulfate and remove solvent to obtain 2.52 g product. MS (m/e): 297.0/299.0 (M+H).

後処理

  1. additionPour
  2. extractionextract with ethylacetate
  3. washWash
  4. dry with materialdry over sodium sulfate
  5. customremove solvent

出典と根拠

ORDレコード
ord-c03efdef1d594c498a5dc8be1f6972cb
出典データセット
uspto-grants-2009_08
特許番号
US07576108B2

反応ノート

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