Water → Benzyl 2-bromo-5-nitrobenzoate

HRID 2103750ノート

反応式

HRID 2103750 の反応式
[Br:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].C(=O)([O-])[O-].[K+].[K+].O>CN(C=O)C.C(Br)C1C=CC=CC=1>[CH2:4]([O:5][C:4](=[O:6])[C:3]1[CH:7]=[C:8]([N+:11]([O-:13])=[O:12])[CH:9]=[CH:10][C:2]=1[Br:1])[C:3]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:2]=1

参加物

6

反応物 3

HCID 962WaterHCID 11430Potassium CarbonateHCID 2430252-Bromo-5-nitrobenzoic acid

生成物 1

HCID 19038758Benzyl 2-bromo-5-nitrobenzoate収率 187.7%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 7498Benzyl Bromide溶媒

実験手順

Under an atmosphere of argon, to a solution of 2-bromo-5-nitrobenzoic acid (5.14 g) in DMF, benzyl bromide (2.73 mL) and potassium carbonate (4.33 g) were added. The mixture was stirred for 30 minutes at room temperature. To the reaction mixture, water was added, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and a saturated aqueous solution of sodium chloride, dried over magnesium sulfate and concentrated. The residue was washed with hexane/ethyl acetate to give the title compound (6.59 g) having the following physical data.

後処理

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe organic layer was washed with water
  3. dry with materiala saturated aqueous solution of sodium chloride, dried over magnesium sulfate
  4. concentrationconcentrated
  5. washThe residue was washed with hexane/ethyl acetate

出典と根拠

ORDレコード
ord-096c688eeb30442b9eadb70c82d7af4a
出典データセット
uspto-grants-2009_08
特許番号
US07576129B2

反応ノート

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