1,1'-Thiocarbonyldi-2(1H)-pyridone → 4-Methoxycarbonyl-3-nitrophenyl isothiocyanate

HRID 2103818

反応式

HRID 2103818 の反応式
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([N+:12]([O-:14])=[O:13])[CH:3]=1.[C:15](N1C=CC=CC1=O)(N1C=CC=CC1=O)=[S:16]>ClCCl>[CH3:9][O:8][C:6]([C:5]1[CH:10]=[CH:11][C:2]([N:1]=[C:15]=[S:16])=[CH:3][C:4]=1[N+:12]([O-:14])=[O:13])=[O:7]

参加物

4

反応物 2

HCID 8531621,1'-Thiocarbonyldi-2(1H)-pyridoneHCID 14730691Methyl 4-amino-2-nitrobenzoate

生成物 1

HCID 860145914-Methoxycarbonyl-3-nitrophenyl isothiocyanate収率 70.5%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of the above synthesized methyl 4-amino-2-nitrobenzoate (50 mg, 0.25 mmol) and 1,1′-thiocarbonyldi-2(1H)-pyridone (59 mg, 0.25 mmol) in dichloromethane (4.2 ml) was stirred at room temperature for 3 hours. After completion of the reaction, the solvent was evaporated, followed by purification with a silica gel column chromatography to obtain 42 mg of the desired product as a colorless oil (yield 69%).

後処理

  1. customAfter completion of the reaction
  2. customthe solvent was evaporated
  3. customfollowed by purification with a silica gel column chromatography

出典と根拠

ORDレコード
ord-7736916130734166a97567cd54cd8f85
出典データセット
uspto-grants-2009_08
特許番号
US07576115B2

関連ノート

読み込み中…