Quinoxaline-6-carbohydrazide → Quinoxaline-6-carboxylic acid {1-[5-(3,4-dichlorophenyl)-4-hydroxy-thiophen-3-yl]-ethylidene}-hydrazide

HRID 2103925

反応式

HRID 2103925 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[S:10][CH:11]=[C:12]([C:15]([CH3:17])=O)[C:13]=2[OH:14])[CH:5]=[CH:6][C:7]=1[Cl:8].[N:18]1[C:27]2[C:22](=[CH:23][C:24]([C:28]([NH:30][NH2:31])=[O:29])=[CH:25][CH:26]=2)[N:21]=[CH:20][CH:19]=1>CS(C)=O>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[S:10][CH:11]=[C:12]([C:15](=[N:31][NH:30][C:28]([C:24]3[CH:23]=[C:22]4[C:27](=[CH:26][CH:25]=3)[N:18]=[CH:19][CH:20]=[N:21]4)=[O:29])[CH3:17])[C:13]=2[OH:14])[CH:5]=[CH:6][C:7]=1[Cl:8]

参加物

4

反応物 2

HCID 4657453Quinoxaline-6-carbohydrazideHCID 442072882-(3,4-Dichlorophenyl)-3-hydroxy-4-(methylcarbonyl)thiophene

生成物 1

HCID 72359927Quinoxaline-6-carboxylic acid {1-[5-(3,4-dichlorophenyl)-4-hydroxy-thiophen-3-yl]-ethylidene}-hydrazide収率 10%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

A solution of 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (25 mg, 0.087 mmol) and quinoxaline-6-carboxylic acid hydrazide (25 mg, 0.087 mmol) in dimethylsulfoxide (0.5 mL) was stirred at 100° C. for 12 hours and the reaction mixture was concentrated under the reduced pressure. To the residue was added chloroform and the precipitated solid was collected by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (yield 10%).

後処理

  1. concentrationthe reaction mixture was concentrated under the reduced pressure
  2. additionTo the residue was added chloroform
  3. filtrationthe precipitated solid was collected by filtration
  4. customdried by means of a vacuum pump

出典と根拠

ORDレコード
ord-eacb75e3d13c4703b3457753d79a0f97
出典データセット
uspto-grants-2009_08
特許番号
US07576115B2

関連ノート

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