1,8-Diiodooctane → 5-(8-(3H-1,2,3-triazol-4-ylthio)octylthio)-1H-1,2,3-triazole

HRID 2103942ノート

反応式

HRID 2103942 の反応式
[SH:1][C:2]1[NH:6][N:5]=[N:4][CH:3]=1.I[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]I>C(O)C>[N:4]1[CH:3]=[C:2]([S:1][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][S:1][C:2]2[NH:6][N:5]=[N:4][CH:3]=2)[NH:6][N:5]=1

参加物

4

反応物 2

HCID 906051,8-DiiodooctaneHCID 178527741HCID 178527741、化合物2 回

生成物 1

HCID 1784209285-(8-(3H-1,2,3-triazol-4-ylthio)octylthio)-1H-1,2,3-triazole収率 42%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

20 mmole of 5-mercapto-1H-1,2,3-triazole (sodium salt) was dissolved in 20 ml of ethanol in stirring. 10 mmole of 1,8-diiodooctane was added dropwise to the solution of 5-mercapto-1H-1,2,3-triazole (sodium salt), and stirred overnight. After the solvent was evaporated in vacuum, the residual was washed with 50 ml pure H2O for three times, and then with 50 ml hexane for 3 times. At last, the residual was dried in oven at 60° C. for 24 hours. 1.30 g product was obtained as white solid. Yield: 42%. 1H NMR (DMSO): δ (ppm) 7.88 (2H, s), 2.86 (4H, t, JH-H=7.14), 1.50 (4H, m), and 1.20-1.31 (8H, m).

後処理

  1. stirringstirred overnight
  2. customAfter the solvent was evaporated in vacuum
  3. washthe residual was washed with 50 ml pure H2O for three times
  4. customAt last, the residual was dried in oven at 60° C. for 24 hours

出典と根拠

ORDレコード
ord-2fee72b930914d4face73da053944f0d
出典データセット
uspto-grants-2009_08
特許番号
US07576165B2

反応ノート

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